This article proposes a novel combustion mode, namely multiple premixed compression ignition (MPCI), in gasoline direct-injection compression ignition (GDICI) regime. Its predominant feature is the multiple premixed combustion processes in a sequence of spraycombustionspraycombustion around the compression top dead center. The multiple-stage premixed combustion decouples the pressure rise with the pollutant formation process. With optimization, it can lower the rate of pressure rise and emissions simultaneously while achieving high thermal efficiency. The experimental study has been carried out in a single-cylinder research engine with a compression ratio of 18.5. Gasoline with the research octane number of 66 was tested under MPCI mode with different exhaust gas recirculation rates and injection timings. Compared to the single-stage diffusion combustion mode of conventional diesel engines, the low octane gasoline MPCI mode achieves lower emissions of smoke, NO, and CO as well as greater thermal efficiency, with a penalty of greater total hydrocation emissions.