폴리아크릴산이 그라프트된 다공성 폴리우레탄막을 통한 약물의 방출조절

김진홍; 이영무; 정창남

Journal of the Korean Industrial and Engineering Chemistry, Vol.3, No.2, 296-304, June, 1992

Export Citation

폴리아크릴산이 그라프트된 다공성 폴리우레탄막을 통한 약물의 방출조절

Controlled Drug Delivery through Poly(acrylic acid-g-urethane) Porous Membrane

김진홍, 이영무, 정창남

초록

본 연구에서는 pH 및 용매조성의 변화에 따라 투과도가 변화하는 고분자막을 제조하고자 다공성 폴리우레탄 대칭막을 상전이법에 의해서 제조하고 다공성 대칭막의 표면에 친수성 고분자를 그라프트시켰다. 다공성 대칭막은 응고조로 DMSO/메탄올을 이용하여 얻을 수 있었다 또한 ceric ammonium nitrate (CAN)를 이용하여 다공성 대칭막 표면에 폴리아크릴아미드를 그라프트시키고, 가수분해하여 폴리아크릴산이 그라프트된 다공성 대칭막을 얻었다. 친수성 고분자가 그라프트된 고분자막을 통한 pH 및 용매조성의 변화에 따른 투과도의 변화를 비타민 B₂인 리보플라빈을 이용하여 검토하였다. pH에 따른 투과도의 변화는 폴리아크릴산이 그라프트된 경우 pH가 감소함에 따라 투과도는 증가하였으며 또한 용매조성에 따른 투과도의 변화는 비용매에 대한 용매의 양이 증가함에 따라서 증가하였다.

Porous polyurethane membrane was prepared by the phase inversion process with variable permeability in response to pH and solvent composition. Hydrophilic polymers were grafted on the surface of the symmetric porous membrane. Porous polyurethane membrane was obtained in DMSO/methanol. It was subsequently grafted with acrylamide on the surface with ceric ammonium nitrate(CAN) as a initiator, followed by the hydrolysis to obtain poly(acrylic acid-g-urethane) (PAA-g-PU) membrane. The change in permeability of vitamine B₂(riboflavin) was investigated through PAA-g-PU. For PAA-g-PU membrane, permeability increased with the decrease in pH, and with an increase in solvent content in sink solution.

[References]

Ishihara K, Kobayashi M, Ishimura N, Shinohara I, Polym. J., 16, 625 (1984)
Kost J, Horbert TA, Ranter BD, Singh M, J. Biomed. Mater. Res., 19, 1117 (1985)
Iwata H, Matsuda J, Jpn. J. Artif. Org., 16, 1386 (1987)
Firestone BA, Siegel SA, Polym. Commun., 29, 294 (1988)
Osada Y, Kishi R, Umezawa K, Yasunaga H, Maekawa S, Jpn. J. Artif. Org., 17, 466 (1988)
Momiyama M, Kakiuchi T, Kinoshita T, Takizawa A, Tsujita Y, Polym. Prepr., 26, 2933 (1987)
Iliopoulous I, Audebert R, Eur. Polym. J., 24, 171 (1988)
Barden KA, Eum KM, Langley K, Tirrell DA, Macromolecules, 20, 454 (1987)
Seki S, Kotaka T, Macromolecules, 19, 978 (1986)
Okahata Y, Handa K, Ohta M, Macromolecules, 20, 15 (1987)
Jager J, Engberts JBFN, Eur. Polym. J., 23, 579 (1987)
Osada Y, Handa K, Ohta M, J. Membr. Sci., 27, 327 (1986)
Iwata H, Matsuda T, J. Membr. Sci., 38, 185 (1988)
Yoshihiro Y, Mario C, Yukio I, "Proc. 3rd World Biomaterials Congress," Kyoto 5P-15 (1988)
Wijmans JG, Baaij JPB, Smolders CA, J. Membr. Sci., 14, 263 (1983)
Kim JH, Kim JY, Kee YM, Kim KY, J. Appl. Polym. Sci., 44, 1823 (1992)
Hebeish A, Mehta PC, J. Appl. Polym. Sci., 12, 1625 (1968)
Feng XD, Sun YH, Oiu KY, Macromolecules, 18, 2105 (1985)
Arnold R, J. Colloid Sci., 12, 549 (1957)

[Referenced By]

[1] Ishihara K, Kobayashi M, Ishimura N, Shinohara I, Polym. J., 16, 625 (1984)

[2] Kost J, Horbert TA, Ranter BD, Singh M, J. Biomed. Mater. Res., 19, 1117 (1985)

[3] Iwata H, Matsuda J, Jpn. J. Artif. Org., 16, 1386 (1987)

[4] Firestone BA, Siegel SA, Polym. Commun., 29, 294 (1988)

[5] Osada Y, Kishi R, Umezawa K, Yasunaga H, Maekawa S, Jpn. J. Artif. Org., 17, 466 (1988)

[6] Momiyama M, Kakiuchi T, Kinoshita T, Takizawa A, Tsujita Y, Polym. Prepr., 26, 2933 (1987)

[7] Iliopoulous I, Audebert R, Eur. Polym. J., 24, 171 (1988)

[8] Barden KA, Eum KM, Langley K, Tirrell DA, Macromolecules, 20, 454 (1987)

[9] Seki S, Kotaka T, Macromolecules, 19, 978 (1986)

[10] Okahata Y, Handa K, Ohta M, Macromolecules, 20, 15 (1987)

[11] Jager J, Engberts JBFN, Eur. Polym. J., 23, 579 (1987)

[12] Osada Y, Handa K, Ohta M, J. Membr. Sci., 27, 327 (1986)

[13] Iwata H, Matsuda T, J. Membr. Sci., 38, 185 (1988)

[14] Yoshihiro Y, Mario C, Yukio I, "Proc. 3rd World Biomaterials Congress," Kyoto 5P-15 (1988)

[15] Wijmans JG, Baaij JPB, Smolders CA, J. Membr. Sci., 14, 263 (1983)

[16] Kim JH, Kim JY, Kee YM, Kim KY, J. Appl. Polym. Sci., 44, 1823 (1992)

[17] Hebeish A, Mehta PC, J. Appl. Polym. Sci., 12, 1625 (1968)

[18] Feng XD, Sun YH, Oiu KY, Macromolecules, 18, 2105 (1985)

[19] Arnold R, J. Colloid Sci., 12, 549 (1957)