In the context of process industries, online monitoring of quality variables is often restricted by inadequacy of measurement techniques or low reliability of measuring devices. Therefore, there has been a growing interest in the development of inferential sensors to provide frequent online estimates of key process variables on the basis of their correlation with real-time process measurements. Representation of multi-modal processes is one of the challenging issues that may arise in the design of inferential sensors. In this paper, Bayesian procedures for the development and implementation of adaptive multi-model inferential sensors are presented. It is shown that the application of a Bayesian scheme allows for accommodating the overlapping operating modes and facilitating the inclusion of prior knowledge. The effectiveness of the proposed procedures are first demonstrated through a simulation case study. The efficacy of the method is further highlighted by a successful industrial application of an adaptive multi-model inferential sensor designed for real-time monitoring of a key quality variable in an oil sands processing unit. (C) 2012 Elsevier Ltd. All rights reserved.