Facility siting has come under increasing scrutiny in recent years and is an important aspect of process safety for plant personnel and their contractors. American Petroleum Institute RP 752 outlines three basic facility siting assessment approaches that can be utilized: a consequence-based approach, a quantified risk assessment approach, and a spacing tables approach. This article summarizes how a risk-based approach to facility siting can provide the best understanding of onsite risks and can enable the most cost-effective resolution of facility siting issues. (c) 2012 American Institute of Chemical Engineers Process Saf Prog, 2012