Journal of the American Chemical Society, Vol.134, No.45, 18570-18572, 2012
Ligand-Enabled Methylene C(sp(3))-H Bond Activation with a Pd(II) Catalyst
Pd(II) insertion into beta-methylene C(sp(3))-H bonds was enabled by a mutually repulsive and electron-rich quinoline ligand. Ligand tuning led to the development or a method that allows for installation of an aryl,, group On a range of acyclic and cyclic amides containing beta-methylene C(sp(3))-H bonds.