화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.134, No.44, 18181-18184, 2012
Baeyer-Villiger C-C Bond Cleavage Reaction in Gilvocarcin and Jadomycin Biosynthesis
GilOII has been unambiguously identified as the key enzyme performing the crucial C-C bond cleavage reaction responsible for the unique rearrangement of a benz[a]anthracene skeleton to the benzo[d]-naphthopyranone backbone typical of the gilvocarcin-type natural anticancer antibiotics. Further investigations of this enzyme led to the isolation of a hydroxyoxepinone intermediate, leading to important conclusions regarding the cleavage mechanism.