화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.20, No.12, 1249-1256, December, 2012
DOI10.1007/s13233-012-0177-0  Export Citation
Formation of Polyion Complex Micelles with Tunable Isoelectric Points Based on Zwitterionic Block Copolymers
Geun-woo Jin, Heejin Kim, Jiyeon Ham, Ji-Hun Seo1, Jong-Sang Park†, and Yan Lee†
  • Department of Chemistry, Seoul National University, Seoul, 151-747, Korea
  • 1Department of Organic Materials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan
E-mail:,
Zwitterionic block copolymers can form polyion complex (PIC) micelles without any additional ionic compounds because their backbones contain both cationic and anionic residues. For the generation of polyion complex(PIC) micelles with tunable isoelectric points (pI), the zwitterionic block copolymers, poly(ethylene oxide)45-b-[poly(2-succinyloxyethyl methacrylate)x-r-poly(2-(dimethylamino)ethyl methacrylate)y] (PEO45-b-(PSEMAx-r-PDMAy)) zwitterionic block copolymers were synthesized via atom transfer radical polymerization (ATRP) of 2-hydroxyethyl methacrylate (HEMA) and 2-(dimethylamino)ethyl methacrylate (DMA), and subsequent succinylation of the hydroxy groups on HEMA. The electrostatic interaction between oppositely charged 2-succinyloxyethyl methacrylate (SEMA) and DMA residues led to spontaneous micelle formation of the zwitterionic block copolymers in an aqueous solution. The pH-dependent protonation/deprotonation behavior of the SEMA and DMA residues induced a change in the net charge of the micelle. Since the pIs of PIC micelles are closely related to the SEMA to DMA ratio (x/y) of the zwitterionic block, PIC micelles with certain pI values, which can be predicted by simple calculations based on the average pKa values of DMA and SEMA, can be easily tailored to achieve our objectives.
Keywords:polyion complex micelle;isoelectric point;zwitterionic block copolymer.
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