화학공학소재연구정보센터
SIAM Journal on Control and Optimization, Vol.46, No.3, 1052-1079, 2007
Antiangiogenic therapy in cancer treatment as an optimal control problem
Antiangiogenic therapy is a novel treatment approach in cancer therapy that aims at preventing a tumor from developing its own blood supply system that it needs for growth. In this paper a mathematical model for antiangiogenic treatments based on a biologically validated model by Hahnfeldt et al. is analyzed as an optimal control problem and a full solution of the problem is given. Geometric methods from optimal control theory are utilized to arrive at the solution.