Przemysl Chemiczny, Vol.91, No.3, 289-294, 2012
Ezetimibe, the drug for lowering the cholesterol level. The development of process for the preparation of a product with high stereochemical purity
Known synthesis of (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)- 2-azetidinon (azetimibe) was improved and optimized to decrease the formation of other diastereoisomers and increase the stereochem. purity of the final product up to above 99%.