The most widely accepted method for determining Hansen’s three-dimensional solubility parameters (3DSP) for crosslinked polymers entails graphically estimating the center of a spherical region in 3DSP-coordinate space whose boundaries are defined in terms of the extent; of swelling by solvents whose 3DSP values are known. In this article, the results of immersion tests performed at 25 degrees C with 53 solvents on each of four commercial polymeric glove materials are used to critically evaluate this method. Analyses reveal a number of serious shortcomings with respect to the reliability of 3DSP estimates obtained. In the context of modeling solubility or other measures of solvent-polymer compatability, it is recommended that alternative methods be sought for determining 3DSPs for crosslinked polymers.