A broad, consistent set of process safety management metrics and leading indicators is important to effectively manage process safety and prevent incidents, help ensure regulatory compliance, meet internal policies, and verify that adequate management attention and resources are allotted to meet program needs. this article will review the development, current state, and future focus areas associated with the use of process safety metrics and leading indicators within The DuPont Company as a global manufacturing organization at a site, business, and corporate level. this includes a historical perspective of past metrics and their technical basis with a primary focus on incident classification and audit results, a review of recent improvements involving an expanded group of current metrics, and a general discussion of forward looking additional improvements. An overview of lessons learned, guidance, and challenges involving the development and use of process safety metrics and indicators within a global enterprise will also be provided. (C) 2009 American Institute of Chemical Engineers Process Saf Prog 28: 147-155,2009