In this paper, the conversion of methane to methanol on CuO/Al(2)O(3) and Mo-CuO/Al(2)O(3) catalysts in a plasma reactor was tested. A comparison between catalytic and plasma-catalytic systems had been made in tested temperature range of 50-300A degrees C. Experimental results showed that plasma-catalytic system demonstrated a much better methane conversion than catalytic system in tested temperature range and Mo-CuO/Al(2)O(3) revealed a higher catalytic activity than CuO/Al(2)O(3) for methanol synthesis. Furthermore, an Arrhenius plot was made in order to deduce the mechanism of plasma activation, which revealed that the presence of plasma decreased the activation energy for both catalysts. In the case of Mo-CuO/Al(2)O(3) catalyst, the enhanced activity for methanol synthesis was assumed due to the oxygen vacancies on Mo-CuO/Al(2)O(3) catalyst, which can utilize plasma-induced species to improve the catalytic efficiency.