The polyurethane networks were based on poly(ethylene glycol) 6000 (PEG), crosslinked with 1,1,1-tris(hydroxy methyl)ethane and with the stoichiometric equivalence of hexamethylene diisocyanate. Radioactive steroids were incorporated into cylindrical hydrogels over a wide range of compositions. The release profiles were drawn from dried down hydrogel of polyurethane networks. The scintillation counter was used for the release study of steroids after different intervals. In vivo, the loaded hydrogels were implanted into rats. The results for constant release studies were recorded.