The crystal structure of the 1222-type ruthenocuprate RuSr2Nd0.9Y0.2Ce0.9Cu2O10 has been studied by time-of-flight neutron diffraction at temperatures 100-160 K and pressures up to 5 GPa. The structure has tetragonal I4/mmm symmetry throughout (e.g. a = 3.8104(2) angstrom and c = 28.125(3) angstrom at 160 K and 5.1 GPa) with no significant distortions observed at the 140 K Ru spin ordering transition. The strongly bonded Cu-O and Ru-O network leads to a bulk modulus of 145 GPa which is high for layered cuprates, with a low anisotropy in the cell compressibility (k(c)/k(a) = 1.32). The Cu-O-Cu buckling angle and the tilting of the CuO5 square pyramids decreases with pressure, but the in-plane rotation of the RuO6 octahedra increases. (C) 2006 Elsevier Ltd. All rights reserved.