Pulverization experiments with pulverization pots of various sizes were conducted to study the effect of scale-up on the pulverization of woody biomass. The diameter and length of the pots were varied, and the effect of pot-size change on the grindability and productivity of woody biomass was evaluated. From the results, the production rate of woody powder and the energy consumption for woody biomass pulverization in a large-scale vibration mill were estimated. It was found that the pot size significantly influenced the grindability and productivity. With increasing pot diameter, productivity also increased, but grindability as evaluated by the crystallinity index of cellulose decreased significantly. On the other hand, grindability was not notably influenced by the pot length. In a scale-up simulation, the increase in power consumption markedly exceeded the increase of productivity when the pot diameter was increased, and energy consumption per unit of woody powder production also increased significantly. Scale-up of the pot length was able to reduce the energy consumption, but the productivity of woody powder was still very low.