Lead-free glasses with a low melting temperature (less than 600 degrees C) and good chemical durability are desirable for the sealing process in ceramic and electronic applications. In this study, V2O5, ZnO, BaO, and P2O5 were used to prepare lead-free glasses with a low-melting temperature. The glass forming region, glass transition temperature, softening temperature, thermal stability, X-ray property, and thermal expansion property were investigated in detail in the quaternary system. The dependencies of these properties on composition were quantitatively characterized. The lead-free glass, 34.7 mol%V2O5, 12.9 mol%ZnO, 20.6 mol% BaO and 31.8 mol% P2O5 had high chemical stability, an amorphous structure, high water resistance, and a low melting point. In a sealing examination with a plane fluorescent lamp incorporated in a digital camera, we succeeded in achieving excellent sealing. The prepared lead-free glass exhibited a high performance as a substitute for the commercially available lead glass