To design and analyze a fluidized-bed reaction with high selectivity, a new comprehensive reaction model for fluidized-bed consecutive reactions was developed, and mathematical solutions were derived for the case in which effect of axial gas dispersion in emulsion phase can be ignored (VUME model) and for the case of perfect mixing (PME model). The performance of fluidized-bed reaction was analyzed with these models, and basic parameters affecting and controlling the catalytic reaction in the fluidized-bed and the similarity rule of fluidized-bed reactions were clarified. Based on the similarity rule and comparison with the experimental result of a fluidized-bed consecutive reaction, it was found that a mass-transfer controlling region and a back-mixing controlling region exist in a dense-bed reaction, and the experimental result agreed well with the PME model. It was also concluded that direct contact ratio (N-dc), the mass-transfer capacitance coefficient to reaction rate constant ratio (N-mr), and the consecutive reaction rate constant ratio of catalyst particles (N-rr) play important and effective roles in enhancing the reaction performance, especially selectivity, and the cooperative effect of these parameters is essential for designing a highly selective fluidized-bed reaction.