A study of a small scale Liquid Feed Direct Methanol Fuel Cell (LFDMFC), based on solid polymer electrolyte membrane, is reported. Two flow cell designs, one with a parallel flow channel arrangement and the other with a spot design of flow bed, are used. The structure of the DMFC comprises a composite of two porous electrocatalytic electrodes; Pt-Ru-carbon catalyst anode and Pt-carbon catalyst cathode, on either side of a solid polymer electrolyte (SPE) membrane. The performance of three Pt-Ru catalysts is compared. The influence of the degree of Teflon loading on the electrode structure is also reported. The effect of the following parameters: cell temperature, oxygen gas or air pressure, methanol liquid flow rate and methanol concentration on the power performance is described.