Excess molar enthalpies for four binary systems of methyl acetoacetate (methanol, + ethanol, + 1-propanol, and + 2-propanol) at T = (288.2, 298.2, 313.2, and 328.2) K and p = 101.3 kPa were determined by using a flow-mixing isothermal microcalorimeter. The excess molar enthalpies increase with temperature and the molecular size of the alcohols. The experimental data were correlated by using the Redlich-Kister equation. The densities of the methyl acetoacetate at different temperatures were measured by using a vibrating-tube densimeter.