The yield of crystallization processes is mostly limited by the eutectic points as thermodynamic limits and the economically acceptable temperature level. In some cases it is possible to increase the yield and to improve the crystallization performance by the addition of a dedicated third component. Therefore, a structured solvent screening method is developed to rapidly identify possible solvents to increase the yield and to improve the performance of a crystallization unit if limiting factors are known. For a fast validation, an experimental stage gate process is developed to come up with the required information of each stage at a minimum workload. The developed stage gate process is based completely on thermal analysis using differential scanning calorimetry (DSC). The solvent screening approach and the stage gate process are successfully adopted to investigate the yield maximization of an acrylic acid crystallization from an aqueous melt by adding a third component. For three possible components complete ternary solid-liquid equilibrium diagrams are measured and evaluated.