Softisan 100 is a triglyceride mixture consisting of saturated vegetable fatty acids. Its solubility in two binary mixtures, that is, ethanol + water and acetone + water, was investigated experimentally at the temperature range from (279.95 to 304.45) K. The melting temperature and enthalpy of fusion of Softisan 100 were determined by differential scanning calorimetry (DSC). The Wilson and nonrandom two-liquid (NRTL) models were employed to correlate the experimental data, and the obtained results were compared. The calculated results by the Wilson model with a model parameter (Lambda(ij)) independent of the temperature were found to have a good agreement with the experimental data.