The solid-liquid equilibrium of 2,4-dichloro-5-methoxpyrimidine was first determined ill this article. Using it laser monitoring observation technique, the solubilities of 2,4-dichloro-5-methoxpyrimidine ill ethyl ethanoate, methanol, ethanol, acetone, tetrachloromethane, and heptane have been determined experimentally from (295.60 to 316.39, 302.37 to 316.95, 299.44 to 316.61, 297.35 to 311.37, 298.60 to 312.15, and 299.10 to 320.08) K, respectively. The results are correlated with lambda-h equation and Apelblat equation. The calculated results show that the correlation of the Apelblat model for six measured systems has less deviation than that of the lambda-h equation.