The experimental data of quaternary aqueous solutions of chlorides charge-type 1-1*1-1*1-1. with a cation (Na+; K+; Li+; NH4+) are determined using the hygrometric method. The quaternary systems NH4Cl + NaCl + KCl + H2O, NH4Cl + NaCl + LiCl + H2O, NH4Cl + KCl + LiCl + H2O, and NaCl + LiCl + KCl + H2O have been studied at the temperature 298.15 K. The water activities are measured at total molalities from 0.60 mol.kg(-1) up to saturation for different ionic strength fractions y of NH4Cl or NaCl, gamma = 0.20, 0.50, and 0.80, and z ratio ionic strength for other solutes, with z = 0.20, 0.50, and 0.80 for each y. The obtained data allow the deduction of osmotic coefficients. The ionic interaction model with our approach is developed and determined the mixing ionic parameters phi and chi for quaternary systems. From these results, the mixing ionic parameters phi and chi are used to predict the solute activity coefficients in the mixtures. The results are compared with experimental data.