The solubilities of clindamycin phosphate in different solvents (methanol, ethanol, and dimethyl sulfoxide) were measured at temperatures from (283.15 to 333.15) K by a synthetic method at atmospheric pressure. The experimental data were correlated with the modified Apelblat equation. The equation was found to provide an accurate representation of the experimental data. The dissolution enthalpy determined from the experimental solubility data was also presented.