Experimental results are reported for the solubility of beta-carotene in six binary mixed solvents formed by 2,5,8-trioxanonane with 1-hexene, cyclohexane, hexane, and toluene and by 1-hexene with 2-propanone and cyclohexanone at 293.15 K. A spectral colorimeter was used for analysis of beta-carotene concentration. The beta-carotene solubility in the pure solvents increases in the order: 2-propanone < hexane < 2,5,8-trioxanonane < 1-hexene < cyclohexane < cyclohexanone < toluene. The solubility data as a function of the binary solvent mass fractions were smoothed by the Myers and Scott equation for asymmetric functions. The Flory and Huggins theory of non-athermal mixtures and the Acree and Rytting model were used for prediction of experimental data for the solubility of beta-carotene in the six binary above listed mixed solvents.