Experimental results are reported for the solubility of β-carotene in six binary mixed solvents formed by tert-butyl methyl ether or tert-amyl methyl ether with cyclohexane, hexane, and toluene at 293.15 K. A spectral colorimeter was used for the analysis of P-carotene concentration. The β-carotene solubility in the pure solvents increases in the order hexane < tert-butyl methyl ether < tert-amyl methyl ether < cyclohexane < toluene. The solubility data as a function of the binary solvent mole fractions were correlated by the Myers and Scott equation. Results of these measurements were used to test the predictive ability of β-carotene solubility in the binary mixed solvents using the Treszczanowicz and the Acree and Rytting models. Both models qualitatively predict the solubility of β-carotene in the above-mentioned mixed solvents.