This work reports the experimental results for the carbon dioxide (CO2) + fluoromethane (R41) system obtained using the Burnett method. The apparatus was calibrated using helium. For mixtures, the composition was found by gas chromatographic analysis of the sample collected during expansions. The gas chromatograph was calibrated precisely using samples prepared by the gravimetric method. From the PVT data collected, the second and third virial coefficients were derived for R41 covering the temperature range from 303 to 343 K. The second and third cross virial coefficients were derived from the PVTx measurements for the CO2 + R41 system at T = (303, 313, 323, 333, and 343) K. The second virial coefficients for pure R41 show a good consistency with the literature. Due to lack of experimental data in the literature for the CO2 + R41 system, our density measurements were compared with the REFPROP 6.01 prediction, the differences being within 0.6%, which would confirm the good predictive, power of the model for this system and property.