Excess molar entlialpies H-m(E) were measured for binary mixtures containing an alpha,omega-dichloroalkane (from 1,3-dichloropropane to 1,6-dichlorohexane) and an alkanol (1-butanol or 1-heptanol) using a Calvet microcalorimeter at 298.15 K and normal atmospheric pressure. All mixtures exhibit endothermic behavior for the whole composition range, which means that the rupture of interactions is energetically the most important effect. Experimental values were used to test the predictions of three versions of the UNIFAC group contribution model. The experimental H-m(E) values are discussed in terms of molecular interactions and the proximity effect.