Journal of Adhesion Science and Technology, Vol.25, No.1-3, 151-167, 2011
A Novel Two-Step Procedure for Plasma Surface Modification of Low-Density Polyethylene for Improved Drug Adhesion in Intra Uterine Devices (IUDs)
The Intrauterine Devices (IUDs) are unable to prevent STDs (Sexually Transmitted Diseases) and PIDs (Pelvic Inflammatory Diseases) which seriously restricts their usage. RISUG (R) (Reversible Inhibition of Sperm under Guidance), a potent spermicidal and antimicrobial drug is being coated over copper-T frame (made of polyethylene) by exposing it to vacuum plasma treatment twice to increase the adhesion property of polyethylene. First, the polyethylene alone is exposed to certain process conditions of RF (radiofrequency) plasma which increases the surface roughness by creating micro-and nano-pores (as indicated by scanning electron microscopy and atomic force microscopy). Thereafter RISUG (R) is smeared over the polyethylene of copper-T frame and subjected to the same plasma treatment again. The second plasma treatment causes a "micro-hammering" effect, pushing the drug in the pores and pits formed by the first plasma treatment, resulting in improved bonding. The present study shows that RF plasma treatment alters the surface properties of the copper-T frame without affecting its mechanical properties or primary fabrication. (C) Koninklijke Brill NV, Leiden, 2011