An original method was designed to estimate rheological parameters in the situation when an extensive theological examination of a material is not possible. Particularly, the approach is intended to be used in the examination of blood flow patterns in human vascular system allegedly leading to aneurysm disease. The approach belongs to a class called fluid-structure interaction (FSI) and requires consecutive application of CFD, CSD and CMD. Good agreement was achieved between simulation and experimental results obtained from a specially designed set-up.