This paper presents the results of investigation on uptake of radioactive species Sr-90 and Cs-137 present in the liquid effluents from nuclear processing plants. Chemical precipitation process is adopted to remove radioactivity from the effluents with low and intermediate level of activity. In this process, radioactive Sr-90 and Cs-137 are co-precipitated along with copper ferrocyanide, ferric hydroxide and either calcium phosphate or barium sulphate. These precipitates being fine in size require flocculation for enhanced settling rate in clarifier/thickener. The flocculation by some selected high molecular weight polyacrylamide based polymers has improved the uptake of radioactive metal ions. The adsorption of these radioactive species has been found to increase in the presence of these flocculants thereby improving the decontamination factor (DF). While flocculating the precipitates, there may be some complex fort-nation with Sr2+/Cs+, flocculant and the substrate. This has enhanced the uptake of the radioactive metal ions from the liquid component. The plant trials have indicated the improvement of DF value due to flocculation by cationic flocculant. (c) 2006 Elsevier B.V. All rights reserved.