검색결과 : 11건
| No. | Article |
|---|---|
| 1 |
Activation of the GLP-1 receptor by a non-peptidic agonist Zhao PS, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D Nature, 577(7790), 432, 2020 |
| 2 |
Structural basis of G(s) and G(i) recognition by the human glucagon receptor Qiao AN, Han S, Li XM, Li ZX, Zhao PS, Dai AT, Chang R, Tai LH, Tan QX, Chu XJ, Ma LM, Thorsen TS, Reedtz-Runge S, Yang DH, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu BL Science, 367(6484), 1346, 2020 |
| 3 |
Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism Liu S, Jean-Alphonse FG, White AD, Wootten D, Sexton PM, Gardella TJ, Vilardaga JP, Gellman SH Journal of the American Chemical Society, 141(37), 14486, 2019 |
| 4 |
O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity Levine PM, Balana AT, Sturchler E, Koole C, Noda H, Zarzycka B, Daley EJ, Truong TT, Katritch V, Gardella TJ, Wootten D, Sexton PM, McDonald P, Pratt MR Journal of the American Chemical Society, 141(36), 14210, 2019 |
| 5 |
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao PS, Clydesdale L, Koole C, Truong TT, Thal DM, Lei SF, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D Nature, 555(7694), 121, 2018 |
| 6 |
Structure of the adenosine-bound human adenosine A(1) receptor-G(i) complex Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A Nature, 558(7711), 559, 2018 |
| 7 |
Cryo-EM structure of the active, G(s)- protein complexed, human CGRP receptor Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM Nature, 561(7724), 492, 2018 |
| 8 |
Allostery and Biased Agonism at Class B G Protein-Coupled Receptors Wootten D, Miller LJ, Koole C, Christopoulos A, Sexton PM Chemical Reviews, 117(1), 111, 2017 |
| 9 |
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM Nature, 546(7656), 118, 2017 |
| 10 |
beta-Arrestin-Biased Agonists of the GLP-1 Receptor from beta-Amino Acid Residue Incorporation into GLP-1 Analogues Hager MV, Johnson LM, Wootten D, Sexton PM, Gellman SH Journal of the American Chemical Society, 138(45), 14970, 2016 |