화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2003년 봄 (04/25 ~ 04/26, 순천대학교)
권호 9권 1호, p.54
발표분야 고분자
제목 Release Behaviors of Biodegradable Poly(l-lactide)/Poly(ethylene glycol) Microcapsules
초록 Biodegradable polymers have become increasingly important in the development of drug delivery systems. In this work, biodegradable poly(l-lactide) (PLA)/poly(ethylene glycol) (PEG) microcapsules are investigated in the degradation, size distribution, and drug release behavior. The degradation of PLA/PEG is much faster than that PLA, that is, the mass of PLA recovered in 3 week is 70.0%, whereas the degradations of PLA/PEG containing 5 and 10 wt% PEG are 51.8% and 39.1%, respectively. Such a result is comprehensible from the viewpoint that PLA/PEG is more hydrophilic, due to a relatively carboxylic acid end group of PEG. The particle size of the PLA microcapsules is smaller than that made from PLA/PEG copolymers under the same conditions, due to the swelling characteristics of the ethylene glycol. Drug release from microcapsules is effected by the properties of PLA/PEG copolymers determined by UV/Vis. spectra. It is found that the drug release rates of the microcapsules are significantly increased with adding of PEG, which is explained by higher hydration rate and swelling characteristics of the ethylene glycol.
저자 김승학, 박수진
소속 한국화학(연)
키워드 Microcapsule; poly(l-lactide); poly(ethylene glycol); release behavior
E-Mail kshak@krict.re.kr, psjin@krict.re.kr