| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Mechano-active tissue engineering of vascular smooth muscle using pulsatile perfusion bioreactors and collagen/cell incorporating elastic scaffold |
| 초록 |
In this study, we hypothesized that pulsatile strain and shear stress stimulate VSM tissue development and induce VSMCs to retain the differentiated phenotype on a collagen/smooth muscle cells mixture in vitro. To test the hypothesis, rabbit aortic smooth muscle cells were seeded onto rubber-like elastic, three-dimensional PLCL [poly(lactide-cocaprolactone),50:50] scaffolds and subjected to pulsatile strain and shear stress by culturing them in pulsatile perfusion bioreactors for up to 8 weeks. As control experiments, VSMCs were cultured on PLCL scaffolds statically. The pulsatile strain and collagen/cell incorporating elastic scaffold enhanced the VSMCs proliferation and collagen production. |
| 저자 |
박인수1, 김상헌1, 김영하2, 김수현1, 김익환3
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| 소속 |
1한국과학기술(연), 2광주과학기술(연), 3고려대 |
| 키워드 |
Mechano-active tissue engineering; elastic scaffold; pulsatile perfusion bioreactors; collagen
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| E-Mail |
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