| 초록 |
Of the many candidate materials considered for tissue engineering applications, hyaluronic acid, or hyaluronan (Hya) has been demonstrated to have excellent potential as a biomaterial. Hyaluronic acid (Hya) plays a vital role in many tissues, influencing water content and mechanical function, and has been shown to have positive biological effects on cell behavior in vitro. In this study, the composite nanofibers consisting of two types of fibers (titania [TiO2] and hydroxyapatite [HA, Ca10(PO4)6(OH)2]) were fabricated to make up the weak mechanical properties of hydroxyapatite. The composite scaffolds were compared and analyzed by SEM, XRD, XPS, and FTIR techniques and in vitro test. The potential for use of this nanocomposite as bone scaffolds was assessed by osteoblastic cell (MC3T3-E1) in terms of attachment, proliferation and differentiation. |
