| 학회 |
한국공업화학회 |
| 학술대회 |
2008년 가을 (11/12 ~ 11/14, ICC 제주) |
| 권호 |
12권 2호 |
| 발표분야 |
생물공학 |
| 제목 |
Screening of β-2 microglobulin binding and aggregation ligand |
| 초록 |
β-2 Microglobulin (β2m) is a major protein constituent of dialysis-related amyloidosis. It can aggregate into amyloid fibers and deposit in joint spaces. The incubation of β2m in vitro under acidic condition in the presence of seed fibril results in the formation of amyloid fibril. But the generation of amyloid fibrils under physiological conditions at is difficult. Our research has been focused on the screening of ligands which can bind and initiate the aggregation of β2m monomer. β-2 Microglobulin fibril faction or seed and synthetic peptide libraries were coupled on HiCore resin bead and tested for their removal activity of β2m. |
| 저자 |
김미라, 최정현, 안민구, 강성수, 백승렬, 이윤식
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| 소속 |
서울대 |
| 키워드 |
β-2 microglobulin. resin bead; peptide
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| E-Mail |
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