| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Metal-organic Frameworks, NH2-MIL-88(Fe), as Carriers for Ophthalmic Delivery of Brimonidine |
| 초록 |
We have proposed a metal-organic framework (MOF), NH2-MIL-88(Fe), as a novel carrier for topical drug delivery to the eye. The NH2-MIL-88(Fe) particles were prepared via a solvothermal synthesis method. When brimonidine (BMD), an anti-glaucoma medicine, was encapsulated into NH2-MIL(Fe)-88 (i.e., NH2-MIL-88(Fe)/BMD), the drug was loaded at 121.3 µg/mg and released in a sustained manner for up to 12 h. The NH2-MIL-88(Fe)/BMD exhibited mucoadhesive properties and remained on rabbit eyes for a period of up to 4 h. Consequently, a high concentration of brimonidine was found in aqueous humor for a prolonged period after the administration of NH2-MIL-88(Fe)/BMD, which resulted in a greater than two-fold increase in drug bioavailability and activity period compared with those of Alphagan P. Hence, NH2-MIL-88(Fe) is suggested to be a promising carrier for topical delivery to the eye that provides enhanced bioavailability of ocular drugs. |
| 저자 |
김세나1, 박천권2, 허범강1, 민창희1, 천내영1, 최영빈1
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| 소속 |
1서울대, 2성균관대 |
| 키워드 |
Metal-organic framework; Ocular drug delivery; Glaucoma; Brimonidine; Glaucoma; Mucoadhesion
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| E-Mail |
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