| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Polypeptide ionic complexes nanoparticles for model drug delivery. |
| 초록 |
We designed polypeptide-based ionic complexes nanoparticles for intracellular delivery of model biopharmaceuticals. The polymer was synthesized by sequential ring-opening polymerization of N-carboxy anhydrides of cbz-L-lysine, followed by N-carboxy anhydrides of L-alanine. Then, deprotection of protecting groups to produce PEG-PK-PA triblock copolymer. This polymer can make ionic complexes with hyaluronic acid. Each complexes have different zeta potential depending on the PEG-PK-PA to HA ratio. The ionic complexes nanoparticles encapsulated FITC-BSA were internalized into HeLa cells. |
| 저자 |
고두영, 김승진, 정병문
|
| 소속 |
이화여자대 |
| 키워드 |
ionic complexes nanoparticles; intracellular delivery
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| E-Mail |
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