| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Internalization of polypeptide based nanoparticels into the cell. |
| 초록 |
Cellular uptake of macromolecules have been intensively studied for biomolecular delivery to cytosol. In this study, positively charged core-shell polypeptides were complexed with hyaluronic acid and positively charged macromolecular model drug to forms zero-charged nanoparticles. Mechanism of intracellular delivery of these nanoparticles were investigated by the cell internalization inhibitors such as chlorpramazine, filipin and rottlerin. Chlorpromazine significantly inhitiated the intracellular delivery, suggesting that clathrin mediated endocytosis is the main mechanism of the internalization of the nanoparticles. |
| 저자 |
고두영, 정병문, 남상아, 정희정
|
| 소속 |
이화여자대 |
| 키워드 |
nanoparticles; drug delivery; intracellular delivery
|
| E-Mail |
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