| 초록 |
In this talk, we introduce a ‘nanosystem’ comprised of two distinct nanoparticle populations (plasmonic nanoparticles and drug nanocarriers) that communicate and cooperate each other in vivo to amplify drug or imaging payload delivery. We construct a cooperative nanosystem consisting of two discrete nanomaterials. The first component is plasmonic gold nanorod “activators” that populate the porous tumor vessels and act as photothermal nanoantennas to specify tumor heating via remote near-infrared laser irradiation. We find that local tumor heating accelerates the recruitment of the second component: a targeted nanoparticle consisting of either magnetic nanoworms or doxorubicin loaded liposomes. This study demonstrates that the appropriate combination of nanomaterials currently under investigation in cancer therapy can significantly enhance therapeutic efficacy relative to the individual components. Site-specific photothermal heating of plasmonic gold nanorods can engineer the local tumor microenvironment to enhance the accumulation of therapeutic targeted liposomes, which increases the overall hyperthermal and chemotherapeutic tumor-destroying effects. Cooperative, synergistic therapies using plasmonic properties of the nanoparticles could significantly reduce the required dose of anticancer drugs, mitigating toxic side effects, and more effectively eradiating drug-resistant cancers. |
