| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Local Anti-biotic Delivery System for the Treatment of Osteomyelitis |
| 초록 |
Osteomyelitis is a bone infection by microorganism that causes bone damage. Antibiotic-loaded polymethyl methacrylate (PMMA) beads have been commonly adapted to treat the osteomyelitis as a local delivery system. However, the short-term (＜ 2 wks) and partial (＜ 20 % of total antibiotic dose) release from the PMMA beads still remained as critical limitations in clinical field. In this study, we developed a hydrophilized PMMA matrix to continuous and long-term release of an antibiotic, and thus can be an ideal system for the treatment of osteomyelitis. Its drug release behavior, mechanical properties, cytotoxicity, and anti-bacterial effect were investigated. In vivo animal study to investigate its therapeutic effect for the osteomyelitis was also conducted using a rat model (femur osteomyelitis). |
| 저자 |
오은조1, 오세행1, 김한울1, 윤지아1, 이인수1, 권오수2, 이진호1
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| 소속 |
1한남대, 2대전성모병원 정형외과 |
| 키워드 |
Local Antibiotic Delivery System; Osteomyelitis
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| E-Mail |
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