| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
대학원생 구두발표 (발표15분) |
| 제목 |
Fabrication of Gold Nanoshell-formed Nanoparticles Containing Porphrins for Combined Photoherapy of Cancer |
| 초록 |
Photo-active nanoparticles for cancer therapy have been used for photothermal and photodynamic therapy. Photodynamic therapy(PDT) is excellent method for the treatment of cancer. It involves the systemic administration of photosensitizers(PS) like porphyrin, so PS transfers photon energy to generate cytotoxic reactive oxygen species(ROS) to kill cancer. In the case of photothermal therapy(PTT), it involves the conversion of absorbed photon energy into the heat by using gold nanomaterials. In this work, 3rd generation dendrimer porphyrin with 32 carboxyl groups was deposited onto gold nanoshell coated silica nanoparticles via electrostatic interaction. In order to confirm photodynamic and photothemal effect of nanoparticles under light exposure, ROS generation and temperature increase test were conducted. Furthermore, synergetic combined phototherapy including PDT and PTT was achieved through cell viability using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. |
| 저자 |
정의석, 한상원, 김민수, 민지홍, 방혜정, 장우동, 고원건
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| 소속 |
연세대 |
| 키워드 |
: photodynamic therapy; photothermal therapy; gold nanoshell; dendrimer porphyrin
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| E-Mail |
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