| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlling cellular microenvironments to regulate chondrogenic differentiation using synthetic extracellular matrices |
| 초록 |
Cells communicate with adjacent cells and surrounding microenvironments to maintain their viability and phenotype as well as to develop tissues. Specifically cell-cell and cell-matrix interactions are important for chondrocyte growth and development, because cartilage is composed with one type of cells and there is no vessel to transfer nutrient and gas. In this study, cell-matrix and cell-cell interactions of chondrocytes were controlled in vitro using RGD-modification and cell pellet formation, respectively. Chondrogenic differentiation of ATDC5 cells were evaluated using alginate hydrogels by histological and immunohistochemical analysis and quantification of chondrogenic gene expression levels. Considering cell-matrix and cell-cell interactions together in design of synthetic extracellular matrices could be critical to successfully regenerate cartilage tissue in the body. |
| 저자 |
박홍현, 김도윤, 이근용
|
| 소속 |
한양대 |
| 키워드 |
3d culture; chondrocyte; cell-cell interaction
|
| E-Mail |
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