| 초록 |
Postoperative tissue adhesions are caused by the development of abnormal fibrous bands between tissues and organs in response to trauma and infection. It is well known that the tissue adhesions entail severe pain, functional obstruction, and difficult re-operative surgery. In our previous study, we demonstrated that the hyaluronic acid (HA)/mildly crosslinked alginate (ALG) mixture gel can be a good candidate as a tissue adhesion barrier due to its biocompatibility, anti-adhesion property and residence stability at the applied site. In this study, we evenly applied a HA/ALG mixture powder onto the injured peritoneal defect site by spraying, and its role to prevent tissue adhesion during the wound healing and the potential for clinical applications as a tissue adhesion barrier were investigated using a rat model. |
