| 초록 |
In this study, we prepared superparamagnetic iron oxide nanoparticles (IONs) by thermal decomposition method. The synthesized iron oxide nanoparticles were encapsulated with polyaspartamide which is biocompatible, and hydrophilic. Polysuccinimide (PSI) is the backbone of polyaspartamide, which is biocompatible, biodegradable. Multifunctional polymers were grafted on PSI, including hydrophilic O-(2-aminoethyl) polyethylene glycol (PEG) and hydrophobic octadecylamine (C18) for amphiphilic structure, and biotin to interacts with receptors on cancer cell surfaces. The encapsulated IONs were applied for magnetic hyperthermia. The structure of the polyaspartamide was confirmed by 1H NMR and FTIR. The size and distribution size of nanoparticles were defined by Transmission electron microscopy (TEM) and Dynamic light scattering (DLS). The heating efficiency of the nanoparticles was estimate by hyperthermia calorimetric experiment. |
