| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Immune cell-specific delivery of MRI-visible β-Glucan-coated iron oxide nanoparticles for diagnosing liver metastasis |
| 초록 |
In this study, superparamagnetic iron oxide nanoparticles(SPIONs) were coated with β-Glucan in order to target the immune cells residing in the metastatic liver as an aid for discriminating metastasized tumor regions from normal hepatic parenchymal tissue. The morphology of prepared Glu-SPIONs was characterized with DLS and transmission electron microscopy. The cytotoxicity of Glu-SPIONs was analyzed and compared to that of dextran- and PVA-coated SPIONs. The uptake of Glu-SPIONs by peritoneal macrophages was also confirmed with Prussian blue staining and MRI phantom tube imaging. The in vivo uptake of Glu-SPIONs in liver and lymph nodes in a metastatic mouse liver model was tracked by MR imaging after the systemic injection. The Glu-SPION-accumulating regions were further confirmed with H&E staining and Prussian blue staining after tissue sectioning. Based on our study, we propose that Glu-SPIONs can be successfully applied for diagnosing hepatic metastasis. |
| 저자 |
Hieu Vu-Quang1, MUTHUNARAYANAN MUTHIAH1, Hwa Jeong Lee1, You-Kyoung Kim2, Chong Su Cho2, Yong Yeon Jeong3, 박인규1
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| 소속 |
1전남대, 2서울대, 3화순전남대 |
| 키워드 |
b-glucan; SPION; Liver metastasis
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| E-Mail |
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