| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.467 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Physical properties of Chitosan-Alginate-Gelatin scaffold with heating treatment |
| 초록 | Cross-linking reagent should be eliminated from scaffold due to a small amount of cross-linker have cell toxicity. Thus, we made the scaffold using biocompatible natural polymers such as chitosan, alginate and gelatin without cross-linking reagent. Notably, we used heating treatment at 80℃ instead of cross-linking reagent to enhance the biocompatibility of the scaffold. In addition, heating treatment was increased of ionic complex of chitosan, alginate and gelatin by removing the remaining solvent as an acetic acid within scaffold. Physical properties of the scaffold were determined by measuring the solubility in phosphate buffered saline (PBS) and water uptake ability. In result, heating treatment of scaffold prevented the degradation in PBS. Water uptake ability of heating treated scaffold was more increased 2-fold than conventional scaffold using cross-linking reagent. In conclusion, our result suggested that heating treatment of the scaffold to increase mechanical properties and to enhance the biocompatibility could be accepted in the field of transdermal drug delivery system in tissue engineering due to the scaffold supported the optimized environment for the cell growth. Figure 1. Water-uptake ability of scaffold. Table 1. Tensile stress and maximum percent strain of scaffold. |
| 저자 | 최민수1, 한희동1, 김태우1, 박은석2, 신병철1 |
| 소속 | 1한국화학(연), 2성균관대 |
| 키워드 | heating treatment; scaffold; chitosan; alginate; EDC |
