| 초록 |
Recently, there has been substantial interest in theragnostic system as a cancer therapy, as it can provide in simultaneous diagnosis of cancer and targeting drug. In this study, poly(ethylene glycol)-poly(β-benzyl L-aspartate) (PEG-PBLA) block copolymer was synthesized by ring opening polymerization using an amine-functionalized PEG. And then, poly(ethylene glycol)-poly(aspartic acid) (PEG-P(Asp)) was obtained by alkaline hydrolysis reaction of PEG-PBLA with NaOH. An anticancer agent doxorubicin (DOX) and superparamagnetic iron oxide nanoparticles (SPIONs) were successfully encapsulated during self-assembling of PEG-P(Asp) in aqueous media to form homogeneous DOX and SPIONS loaded nanoparticles (PEG-P(Asp)/DOX/SPION) with unimodal size distribution and good colloidal stability. Those results demonstrated that PEG-P(Asp)/DOX/SPION was useful as a new theragnostic nanomedicine due to nano-scaled size, good colloidal stability, biodegradability and high SPIONs loading content. |
