| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.200 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Biodegradable star-shaped poloxamer |
| 초록 | Poloxamer is a triblock copolymer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO). Its micelle and gel properties have been a concern due to its interesting thermosensitive micellization and gelation. At above certain concentration, critical gel concentration (CGC), it forms a gel which has been studied for injectable drug delivery systems. But, poloxamer is not biodegradable and have a high CGC. The erosion rate is too fast to be used for long term delivery of pharmaceutical agents. We designed a star shape biodegradable poloxamer to solve above problems. The star-shape cyclotriphosphazene is synthesized by the reaction of hexachlorotriphosphazene with amine terminated poloxamers. And, their micellization and gelation properties were studied. |
| 저자 | 서주명, 정병문, 손연수 |
| 소속 | 이화여자대 |
| 키워드 | Pluronic; Cyclotriphosphazene; Thermosensitive; Gels; Drug delivery system |
