| 초록 |
Multi-drug resistance (MDR), which is the phenomenon of showing resistance to anticancer drugs, is one of the major barriers in chemotherapy. MDR in cancer cells is often related to the overexpression of efflux pump receptors, such as P-glycoprotein (P-gp). In this study, we have developed melittin and doxorubicin loaded polymersome (Mel-Dox-PL) composed of poly (lactic acid) (PLA)-hyaluronic acid (HA) (20k-10k) di-block copolymers for effective chemotherapy for MDR. Melittin is a basic peptide consisting of 26 amino acid and has the potential as a drug, but the cytotoxicity of melittin has been attributed to both cell necrotic and apoptotic cell. To overcome this problem, we loaded melittin in to polymersome which is a biologically stable drug delivery system. Also, since HA is the most specific ligand for CD44 activiation, the targeting of MDR cells. Our results show that Mel-Dox-PL has a great potential as a novel carrier for MDR cells by regulating p-gp overexpression pathways. |
